Aerosol bronchodilator administration in ventilator systems.

New bronchodilator aerosol preparations.

Correspondence MBIRrNAL 421 hysteria or to altered xnedical perception in the community. Their erroneous conclusions about this illness may impair future investigations of similar outbreaks. It is apparent that the authors failed to do their homework, and demonstrated a surprising lack of information about the principles of epidemiology and of psychiatry. Had they reviewed the literature on the...

Bronchodilator Therapy in Mechanically Ventilated Patients

Introduction Basic Concepts of Aerosol Therapy Inertial Impaction Gravitational Sedimentation Diffusion The Nebulizer The Metered Dose Inhaler Differences during Mechanical Ventilation The Ventilator-Patient Interface Breath Configurations The Airway The Environment The Assessment Evaluation of Lower Respiratory Tract Aerosol Delivery with Bench Models of Mechanical Ventilation Aerosol-Generati...

Inhaled bronchodilator administration during mechanical ventilation.

Inhaled bronchodilators are routinely administered to mechanically ventilated patients to relieve dyspnea and reverse bronchoconstriction. A lower percentage of the nominal dose reaches the lower respiratory tract in a mechanically ventilated patient than in a nonintubated subject, but attention to device selection, administration technique, dosing, and patient-ventilator interface can increase...

Clinical assessment of bronchodilator drugs delivered by aerosol.

Comparison of the Bronchodilator Effects of Aerosol Fenoterol and lsoproterenol*

Aerosolized fenoterol in a dosage of 400 g was compared to Isoproterenol 150 g in 31 asthmatic subjects during the course of a double-blind parallel 90-day study. Bronchodilator activities of the two drugs were evaluated for up to 6 hours on days 1, 45 and 90. Analysis of the data revealed that fenoterol consistently produced a significantly greater increase in FEy1, FEF25-75% and Gaw/YL. Speci...